GIURISATO EMANUELE | Elenco docenti

Insinga G, Tomassetti C, Satasiya V, Gimigliano F, Giordano A, Giurisato E and Morrione A (2026) Progranulin and inflammation-induced cancer: an important player in the tumor microenvironment? Journal of Cellular Physiology. DOI: 10.1002/jcp.70188.
Tomassetti C, Insinga G, Gimigliano F, Morrione A, Giordano A, Giurisato E (2024) Insights into CSF-1R Expression in the Tumor Microenvironment. Biomedicines. Oct 18;12(10):2381. doi: 10.3390/biomedicines12102381. PMID: 39457693.
Bottoni L, Minetti A, Realini G, Pio E, Giustarini D, Rossi R, Rocchio C, Franci L, Salvini L, Catona O, D’Aurizio R, Rasa M, Giurisato E, Neri F, Orlandini M, Chiariello M, Galvagni F. (2024) NRF2 activation by cysteine as a mechanism of survival for Triple Negative Breast Cancer cells. Oncogene Apr 10. doi: 10.1038/s41388-024-03025-0. PMID: 38600165.
Cersosimo F, Lonardi S, Ulivieri C, Martini P, Morrione A, Vermi V, Giordano A and Giurisato E. (2024) CSF-1R in Cancer: More Than a Myeloid Cell Receptor. Cancers, Jan 5;16(2)282. https://doi.org/10.3390/cancers16020282.
Giacomelli M, Monti M, Pezzola DC, Lonardi S, Bugatti M, Missale F, Cioncada R, Melocchi, Giustini V, Villanacci V, Baronchelli C, Manenti S, Imberti L, Giurisato E, Vermi W. (2023) Immuno-contexture and immune checkpoint molecule expression in microsatellite stable/mismatch repair proficient colorectal carcinoma. Cancers 15, 3097. doi.org/10.3390/cancers15123097.
Filiberti S, Russo M, Lonardi S, Bugatti M, Vermi W, Tournier C, and Giurisato E . (2022) Self-Renewal of Macrophages: Tumor-Released Factors and Signaling Pathways. Biomedicines. Oct 26;10(11):2709. doi: 10.3390/biomedicines10112709.PMID:36359228
Zhang J, Pearson A, Sabherwal N, Telfer B, Ali N, Kan K, Xu Q, Zhang W, Chen F, Li S, Wang J, Gray N, Risa-Ebrí B, Finegan KG, Cross M, Giurisato E, Whitmarsh A, and Tournier C. (2022). Inhibiting ERK5 overcomes breast cancer resistance to anti-HER2 therapy by targeting the G1/S cell cycle transition. Cancer Research Communications 2(3): 131-145; doi.org/10.1158/2767-9764.CRC-21-0089.
Monti M, Celli J, Missale F, Cersosimo F, Russo M, Belloni E, Di Matteo A, Lonardi S, Vermi W, Ghigna C, and Giurisato E. (2022) Clinical Significance and regulation of ERK5 expression and function in Cancer. Cancers, 14(2), 348; https://doi.org/10.3390/cancers14020348
Cersosimo F, Barbarino M, Lonardi S, Vermi W, Giordano A, Bellan C and Giurisato E (2021).Mesothelioma malignancy and the microenvironment: molecular mechanisms. Cancers Nov 12;13(22):5664. doi: 10.3390/cancers13225664.
Xu Q, Zhang J, Telfer B, Zhang H, Ali N, Chen F, Risa B, Pearson AJ, Zhang W, Finegan KG, Ucar A, Giurisato E, and Tournier C (2021). The extracellular-regulated protein kinase 5 (ERK5) enhances metastatic burden in triple-negative breast cancer through focal adhesion protein kinase (FAK)-mediated regulation of cell adhesion. Oncogene, 40(23):3929-3941. doi: 10.1038/s41388-021-01798-2.
Cersosimo F, Lonardi S, Bernardini G, Telfer B, Mandelli GE, Santucci A, Vermi W, and Giurisato E (2020). Tumor-Associated Macrophages in Osteosarcoma: from mechanisms to therapy. Int. J. Mol. Sci. 21(15), 5207; doi.org/10.3390/ijms21155207.
Giurisato E, Lonardi S, Telfer B, Lussoso S, Risa-Ebrí B, Zhang J, Russo I, Wang J, Santucci A, Finegan KG, Gray NS, Vermi W, and Tournier C. (2020). Extracellular-regulated protein kinase 5-mediated control of p21 expression promotes macrophage proliferation associated with tumor growth and metastasis. Can Research Jun 19:canres.2416.2019. doi: 10.1158/0008-5472.CAN-19-2416.
Luiz JP, Toller-Kawahisa J, Viacava P, Nascimento D, Pereira P, Saraiva AL, Prado D, Le Bert M, Giurisato E, Tournier C, Cunha TM, Cunha FQ, Quesniaux V, Ryffel B, Alves-Filho JC. (2020). MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression. J Leukoc Biol July 22. doi:10.1002/JLB.1MA0520-016R.
Consoli F, Barbieri G, Picciolini M, Medicina D, Bugatti M, Tovazzi V, Liserre B, Zambelli C, Zorzi F, Berruti A, Giurisato E and Vermi W (2020). Clinical and molecular characterization of a rare complex BRAF mutation involving codon V600 and K601 in primary cutaneous melanoma. Frontiers of Oncology, doi.org/10.3389/fonc.2020.01056.

Ricerca

Pubblicazioni in evidenza:

J Pearson, A., Fullwood, P., Toro Tapia, G., Prise, I., Smith, M., Xu, Q., et al. (2020). Discovery of a gatekeeper residue in the C terminal tail of the extracellular signal-regulated protein kinase 5 (ERK5). INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(3) [10.3390/ijms21030929]. - dettaglio
Moretti, E., Collodel, G., Belmonte, G., Noto, D., Giurisato, E. (2019). Defective spermatogenesis and testosterone levels in kinase suppressor of Ras1 (KSR1)-deficient mice. REPRODUCTION FERTILITY AND DEVELOPMENT, 31(8), 1369-1377 [10.1071/RD18386]. - dettaglio
Benerini Gatta, L., Melocchi, L., Bugatti, M., Missale, F., Lonardi, S., Zanetti, B., et al. (2019). Hyper-Activation of STAT3 Sustains Progression of Non-Papillary Basal-Type Bladder Cancer via FOSL1 Regulome. CANCERS, 11(9) [10.3390/cancers11091219]. - dettaglio
Giurisato, E., Xu, Q., Lonardi, S., Telfer, B., Russo, I., Pearson, A., et al. (2018). Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(12), E2801-E2810 [10.1073/pnas.1707929115]. - dettaglio
Andrew S., G., Paula I., S., Poppy Sephton, C., Aleksandra, B., Richard, H., Giurisato, E., et al. (2017). Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5. SCIENCE ADVANCES, 3(8), Article number e1700898 [10.1126/sciadv.1700898]. - dettaglio

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