SORRENTINO VINCENZO

Vincenzo
Sorrentino
Professore Ordinario

Presentation

EDUCATION AND TRAINING

 1980:           MD, School of Medicine, University of Rome, La Sapienza, Italy, summa cum laude

1980-1983:   Postdoctoral fellow, Laboratory of Virology, Istituto Superiore di Sanita, Rome Italy

1983-1984:   Postdoctoral fellow, Laboratory of Cellular and Molecular Biology, National Cancer Inst., NIH, Bethesda, MD and Frederick Cancer Research Facility, Frederick, MD

1985-1987:   Research Associate, Memorial Sloan-Kettering Cancer Center, New York, N.Y.

 

EMPLOYMENT AND RESEARCH EXPERIENCE

1988-1993:   Staff Scientist, European Molecular Biology Laboratory, Heidelberg, Germany

1993-2000:   Associate Professor of Histology, School of Medicine, University of Siena.

1993-2002:   Director, Growth Factors Unit, DIBIT, Istituto Scientifico San Raffaele, Milano

1994-2000:   Director International PhD Programme, Istituto Scientifico San Raffaele, Milano

2000-date:    Professor of Histology, School of Medicine, University of Siena.

1997-2002:   Director, Medical Genetics Unit, Azienda Ospedaliera Universitaria Senese

2002-2019:    Director, Molecular Medicine & Genetic Unit, Azienda Ospedaliera Universitaria Senese

2019-date     Director, "Programme in Molecular diagnosis and pathogenetic mechanisms of rare genetic diseases", Azienda Ospedaliera Universitaria Senese.

2004-2010:   Director, Center for Stem Cell Research, University of Siena

2009-2011:   Director PhD Programme in Molecular Medicine, University of Siena

2010-2012:   Chairman, Department of Neuroscience, University of Siena

2010-2016:   Vice-Rector for Research, University of Siena

2018-date:    Director, Department of Molecular and Developmental Medicine, University of Siena

 

HONORS

26.11.2016:   Doctor Honoris Causa, (D.H.C.), University of Debrecen, Debrecen, Hungary, 2016

 

BIBLIOMETRIC DATA according to Scopus

Total Articles in international peer reviewed journals:    189

Sum of the Times Cited:                                                8303

H-index:                                                                        50

total Impact Factor February 2019:                                 970.368

 

Research Experience

Vincenzo Sorrentino is an internationally recognized scholar mostly known for his work in the field of molecular cell biology and genetics of skeletal muscle cells. In the last years, his research activity has mainly focused on three main topics.

1) Molecular basis of the assembly of the junctional protein complex at triads.

Following the discovery by his team of the third ryanodine receptors gene (RYR3), Prof. Sorrentino has been interested in the characterization and the assembly of proteins of the excitation-contraction coupling mechanism, like ryanodine receptors, triadin, junction, junctophilins and calsequestrin in skeletal muscle. These studies show how protein-protein interactions mediate the assembly and the stability of a large multiprotein complex around the RYR1 at triads. In recent studies, Prof. Sorrentino and his team identified the molecular determinants by which junctophilins mediate the formation and stability of triads in skeletal muscle.

2) Molecular basis of sarcoplasmic reticulum organization.

In 2003 his team provided the first evidence that an interaction between two proteins, sAnk1.5 and obscurin, stabilizes the sarcoplasmic reticulum around the myofibrils. Additional studies, mainly based on the characterization of knock-out mouse lines lacking either AnkB, sAnk1 or obscurin confirmed the role of muscle-specific ankyrins and obscurin in sarcoplasmic reticulum architecture and the stabilization of the M band and of dystrophin at costamers.

3) molecular genetics of human neuromuscular diseases.

Many of Prof. Sorrentino’s studies have been dedicated to genetic studies aimed to identify the pathogenetic role and the mechanisms altered by mutations in genes encoding proteins of the excitation-contraction coupling in human diseases like Malignant Hyperthermia and Central Core Diseases. In the recent years, Sorrentino provided the first evidence that mutations in the CASQ1 gene are found in patients with Vacuolar Aggregate Myopathy and in patients with Tubular Aggregate Myopathy. More recently, his group identified the first causative mutation in the obscurin (OBSCN) gene in a family with a form of distal myopathy.

 

Curriculum Vitae

Teaching activities

Completion accademic year: 2020/2021

Course year: 2 First cycle degree (DM 270) BIOTECHNOLOGIES A.Y. 2019/2020

Completion accademic year: 2019/2020

Course year: 2 First cycle degree (DM 270) BIOTECHNOLOGIES A.Y. 2018/2019
Course year: 1 Full cicle (6 years) MEDICINE AND SURGERY A.Y. 2019/2020
Course year: 1 Full cicle (6 years) MEDICINE AND SURGERY A.Y. 2019/2020
Course year: 1 Full cicle (6 years) MEDICINE AND SURGERY A.Y. 2019/2020

Completion accademic year: 2018/2019

Course year: 2 First cycle degree (DM 270) BIOTECHNOLOGIES A.Y. 2017/2018
Course year: 1 Full cicle (6 years) MEDICINE AND SURGERY A.Y. 2018/2019
Course year: 1 Full cicle (6 years) MEDICINE AND SURGERY A.Y. 2018/2019
Course year: 1 Full cicle (6 years) MEDICINE AND SURGERY A.Y. 2018/2019

Completion accademic year: 2017/2018

Course year: 2 First cycle degree (DM 270) BIOTECHNOLOGIES A.Y. 2016/2017

Research

Latest publications:

  • Rossi, D., Gigli, L., Gamberucci, A., Bordoni, R., Pietrelli, A., Lorenzini, S., et al. (2020). A novel homozygous mutation in the TRDN gene causes a severe form of pediatric malignant ventricular arrhythmia. HEART RHYTHM, 17(2), 296-304. - view more
  • Iodice, P., Boncompagni, S., Pietrangelo, L., Galli, L., Pierantozzi, E., Rossi, D., et al. (2019). Functional electrical stimulation: A possible strategy to improve muscle function in central core disease?. FRONTIERS IN NEUROLOGY, 10(MAY), 1-11. - view more
  • Pierantozzi, E., Szentesi, P., Al-Gaadi, D., Oláh, T., Dienes, B., Sztretye, M., et al. (2019). Calcium Homeostasis Is Modified in Skeletal Muscle Fibers of Small Ankyrin1 Knockout Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(13), 1-13. - view more
  • Rossi, D., Scarcella, A.M., Liguori, E., Lorenzini, S., Pierantozzi, E., Kutchukian, C., et al. (2019). Molecular determinants of homo- and heteromeric interactions of Junctophilin-1 at triads in adult skeletal muscle fibers. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(31), 15716-15724. - view more
  • Blondelle, J., Marrocco, V., Clark, M., Desmond, P., Myers, S., Nguyen, J., et al. (2019). Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. COMMUNICATIONS BIOLOGY, 2(1), 1-13. - view more