SAPONARA SIMONA

Simona
Saponara
Dipartimento di Scienze della Vita
Professore Associato

Office hours

  • Monday from 09:30 to 11:30
    Place: Studio del docente - Polo Scientifico Universitario di San Miniato
    Note: Previo appuntamento

Contacts

simona.saponara@unisi.it

Curriculum Vitae

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Teaching activities

Completion accademic year: 2023/2024

MODULE II: PHARMACOTHERAPY I
Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2021/2022
PHARMACOLOGY
Course year: 2 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2022/2023

Completion accademic year: 2022/2023

MODULE II: PHARMACOTHERAPY I
Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2020/2021
PHARMACOLOGY
Course year: 2 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2021/2022

Completion accademic year: 2021/2022

MODULE II: PHARMACOTHERAPY I
Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2019/2020
PHARMACOLOGY
Course year: 1 ANESTESIA RIANIMAZIONE, TERAPIA INTENSIVA E DEL DOLORE A.Y. 2021/2022
PHARMACOLOGY
Course year: 2 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2020/2021

Completion accademic year: 2020/2021

MODULE II: PHARMACOTHERAPY I
Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2018/2019
PHARMACOLOGY
Course year: 1 ANESTESIA RIANIMAZIONE, TERAPIA INTENSIVA E DEL DOLORE A.Y. 2020/2021

Completion accademic year: 2019/2020

MODULE II: PHARMACOTHERAPY I
Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2017/2018

Registration for exams

Research

Research Interests

Novel natural as well synthetic modulators of ionic currents (Ca2+ and K+) in vascular smooth muscle cells and cardiomyocytes

Cardiovascular effects of polyphenols

Cardiovascular liabilities of novel multidrug resistance reverting agents and antineoplastic drugs

 

Expertise

Cell viability assays (necrosis, apoptosis, autophagy, cell cycle analysis), mitochondrial function, redox state, cell imaging

Patch-clamp analysis of ionic currents (Na+, Ca2+ and K+ channels, i.e. Kv11.1(hERG) - the target of virtually all QT interval-prolonging torsadogenic drugs) in single cell;

Evaluation of vascular responsiveness to various agents in rat aorta rings and single myocytes

Evaluation of cardiac function and ECG recording in Langendorff-perfused rat heart. Assessment of cardiac damage in homogenized hearts and concentrated coronary effluent (assessment of creatine kinase and troponin T, NT-proBNP)

 

Ultime pubblicazioni:

  • Rango, E., Di Maria, S., Zamperini, C., Poggialini, F., Crespan, E., Perini, C., et al. (2023). Tyrosine Kinase Inhibitor Si409 Has In Vitro and In Vivo Anti-Tumor Activity Against Diffuse Large B-Cell Lymphoma. PHARMACEUTICAL CHEMISTRY JOURNAL, 56(12), 1616-1626 [10.1007/s11094-023-02836-x]. - view more
  • Fedeli, R., Marotta, L., Frattaruolo, L., Panti, A., Carullo, G., Fusi, F., et al. (2023). Nutritionally enriched tomatoes (Solanum lycopersicum L.) grown with wood distillate: chemical and biological characterization for quality assessment. JOURNAL OF FOOD SCIENCE, 1-15 [10.1111/1750-3841.16829]. - view more
  • Luca Michele, D.e., Restuccia, D., Gianfranco Spizzirri, U., Crupi, P., Ioele, G., Gorelli, B., et al. (2023). Wine Lees as Source of Antioxidant Molecules: Green Extraction Procedure and Biological Activity. ANTIOXIDANTS, 12(3) [10.3390/antiox12030622]. - view more
  • Alov, P., Al Sharif, M., Aluani, D., Chegaev, K., Dinic, J., Divac Rankov, A., et al. (2022). A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors. FRONTIERS IN PHARMACOLOGY, 13 [10.3389/fphar.2022.831791]. - view more
  • Federico, S., Khan, T., Fontana, A., Brogi, S., Benedetti, R., Sarno, F., et al. (2022). Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 238, 1-20 [10.1016/j.ejmech.2022.114409]. - view more
All publications