SAPONARA SIMONA

Office hours
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Monday from 09:30 to 11:30Place: Studio del docente - Polo Scientifico Universitario di San MiniatoNote: Previo appuntamento
Curriculum Vitae
Teaching activities
Completion accademic year: 2022/2023
Completion accademic year: 2021/2022
Completion accademic year: 2020/2021
Completion accademic year: 2019/2020
Research
Research Interests
Novel natural as well synthetic modulators of ionic currents (Ca2+ and K+) in vascular smooth muscle cells and cardiomyocytes
Cardiovascular effects of polyphenols
Cardiovascular liabilities of novel multidrug resistance reverting agents and antineoplastic drugs
Expertise
Cell viability assays (necrosis, apoptosis, autophagy, cell cycle analysis), mitochondrial function, redox state, cell imaging
Patch-clamp analysis of ionic currents (Na+, Ca2+ and K+ channels, i.e. Kv11.1(hERG) - the target of virtually all QT interval-prolonging torsadogenic drugs) in single cell;
Evaluation of vascular responsiveness to various agents in rat aorta rings and single myocytes
Evaluation of cardiac function and ECG recording in Langendorff-perfused rat heart. Assessment of cardiac damage in homogenized hearts and concentrated coronary effluent (assessment of creatine kinase and troponin T, NT-proBNP)
Ultime pubblicazioni:
- Papa, A., Pasquini, S., Galvani, F., Cammarota, M., Contri, C., Carullo, G., et al. (2022). Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 246 [10.1016/j.ejmech.2022.114952]. - view more
- Durante, M., Frosini, M., Chiaino, E., Fusi, F., Gamberucci, A., Gorelli, B., et al. (2022). Sdox, a H2S releasing anthracycline, with a safer profile than doxorubicin toward vasculature. VASCULAR PHARMACOLOGY, 143, 1-8 [10.1016/j.vph.2022.106969]. - view more
- Fallani, E., Cevenini, F., Lazzerini, P.E., Verdini, A., Saponara, S. (2022). Off-label use of hydroxychloroquine in COVID-19: analysis of reports of suspected adverse reactions from the Italian National Network of Pharmacovigilance. THE JOURNAL OF CLINICAL PHARMACOLOGY, 62(5), 646-655 [10.1002/jcph.2006]. - view more
- Carullo, G., Falbo, F., Ahmed, A., Trezza, A., Gianibbi, B., Nicolotti, O., et al. (2022). Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: Synthesis and biological evaluation. BIOORGANIC CHEMISTRY, 131, 1-11 [10.1016/j.bioorg.2022.106326]. - view more
- Cuong, N.M., Son, N.T., Nhan, N.T., Fukuyama, Y., Ahmed, A., Saponara, S., et al. (2022). Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators. MOLECULES, 27(14), 4505 [10.3390/molecules27144505]. - view more