SAPONARA SIMONA

Simona
Saponara
Professore Associato

Office hours

  • Monday from 09:30 to 11:30
    Place: Studio del docente - Polo Scientifico Universitario di San Miniato
    Note: Previo appuntamento

Curriculum Vitae

Teaching activities

Completion accademic year: 2022/2023

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2020/2021
Course year: 2 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2021/2022

Completion accademic year: 2021/2022

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2019/2020
Course year: 2 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2020/2021

Completion accademic year: 2020/2021

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2018/2019

Completion accademic year: 2019/2020

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2017/2018
Course year: 1 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2019/2020

Completion accademic year: 2018/2019

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2016/2017

Research

Research Interests

Novel natural as well synthetic modulators of ionic currents (Ca2+ and K+) in vascular smooth muscle cells and cardiomyocytes

Cardiovascular effects of polyphenols

Cardiovascular liabilities of novel multidrug resistance reverting agents and antineoplastic drugs

 

Expertise

Cell viability assays (necrosis, apoptosis, autophagy, cell cycle analysis), mitochondrial function, redox state, cell imaging

Patch-clamp analysis of ionic currents (Na+, Ca2+ and K+ channels, i.e. Kv11.1(hERG) - the target of virtually all QT interval-prolonging torsadogenic drugs) in single cell;

Evaluation of vascular responsiveness to various agents in rat aorta rings and single myocytes

Evaluation of cardiac function and ECG recording in Langendorff-perfused rat heart. Assessment of cardiac damage in homogenized hearts and concentrated coronary effluent (assessment of creatine kinase and troponin T, NT-proBNP)

 

Ultime pubblicazioni:

  • Cuong, N.M., Son, N.T., Nhan, N.T., Fukuyama, Y., Ahmed, A., Saponara, S., et al. (2022). Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators. MOLECULES, 27(14), 4505 [10.3390/molecules27144505]. - view more
  • Alov, P., Al Sharif, M., Aluani, D., Chegaev, K., Dinic, J., Divac Rankov, A., et al. (2022). A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors. FRONTIERS IN PHARMACOLOGY, 13 [10.3389/fphar.2022.831791]. - view more
  • Federico, S., Khan, T., Fontana, A., Brogi, S., Benedetti, R., Sarno, F., et al. (2022). Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 238, 1-20 [10.1016/j.ejmech.2022.114409]. - view more
  • Wang, Z.L., Li, F.F., Quach, R., Ferrarese, A., Forgiarini, A., Ferrari, M., et al. (2022). Nitrobenzoxadiazole derivatives of the rat selective toxicant norbormide as fluorescent probes for live cell imaging. BIOORGANIC & MEDICINAL CHEMISTRY, 59 [10.1016/j.bmc.2022.116670]. - view more
  • Trezza, A., Spiga, O., Mugnai, P., Saponara, S., Sgaragli, G., & Fusi, F. (2022). Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature. EUROPEAN JOURNAL OF PHARMACOLOGY, 918, 174778 [10.1016/j.ejphar.2022.174778]. - view more