SAPONARA SIMONA

Simona
Saponara
Ricercatore universitario

Office hours

  • Monday from 09:30 to 11:30
    Place: Studio del docente - Polo Scientifico Universitario di San Miniato
    Note: Previo appuntamento

Curriculum Vitae

Teaching activities

Completion accademic year: 2021/2022

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2019/2020
Course year: 2 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2020/2021

Completion accademic year: 2020/2021

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2018/2019

Completion accademic year: 2019/2020

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2017/2018
Course year: 1 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2019/2020

Completion accademic year: 2018/2019

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2016/2017
Course year: 1 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2018/2019

Research

Research Interests

Novel natural as well synthetic modulators of ionic currents (Ca2+ and K+) in vascular smooth muscle cells and cardiomyocytes

Cardiovascular effects of polyphenols

Cardiovascular liabilities of novel multidrug resistance reverting agents and antineoplastic drugs

 

Expertise

Cell viability assays (necrosis, apoptosis, autophagy, cell cycle analysis), mitochondrial function, redox state, cell imaging

Patch-clamp analysis of ionic currents (Na+, Ca2+ and K+ channels, i.e. Kv11.1(hERG) - the target of virtually all QT interval-prolonging torsadogenic drugs) in single cell;

Evaluation of vascular responsiveness to various agents in rat aorta rings and single myocytes

Evaluation of cardiac function and ECG recording in Langendorff-perfused rat heart. Assessment of cardiac damage in homogenized hearts and concentrated coronary effluent (assessment of creatine kinase and troponin T, NT-proBNP)

 

Ultime pubblicazioni:

  • Saponara, S., Fusi, F., Iovinelli, D., Ahmed, A., Trezza, A., Spiga, O., et al. (2021). Flavonoids and hERG channels: Friends or foes?. EUROPEAN JOURNAL OF PHARMACOLOGY, 899 [10.1016/j.ejphar.2021.174030]. - view more
  • Lazzerini, P.E., Cartocci, A., Qu, Y.S., Saponara, S., Furini, S., Fusi, F., et al. (2021). Proton pump inhibitors directly block hERG-potassium channel and independently increase the risk of QTc prolongation in a large cohort of US Veterans. CIRCULATION. ARRHYTHMIA AND ELECTROPHYSIOLOGY, 14(7), 638-650 [10.1161/CIRCEP.121.010042]. - view more
  • Carullo, G., Ahmed, A., Trezza, A., Spiga, O., Brizzi, A., Saponara, S., et al. (2021). A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels. BIOCHEMICAL PHARMACOLOGY, 185. - view more
  • Campiani, G., Cavella, C., Osko, J.D., Brindisi, M., Relitti, N., Brogi, S., et al. (2021). Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, 64(14), 9960-9988 [10.1021/acs.jmedchem.1c00184]. - view more
  • Grillo, A., Fezza, F., Chemi, G., Colangeli, R., Brogi, S., Fazio, D., et al. (2021). Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents. ACS CHEMICAL NEUROSCIENCE, 12(9), 1716-1736 [10.1021/acschemneuro.1c00192]. - view more