SAPONARA SIMONA
Office hours
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Monday from 09:30 to 11:30Place: Studio del docente - Polo Scientifico Universitario di San MiniatoNote: Previo appuntamento
Curriculum Vitae
Teaching activities
Completion accademic year: 2025/2026
Completion accademic year: 2024/2025
Completion accademic year: 2023/2024
Research
Research Interests
Novel natural as well synthetic modulators of ionic currents (Ca2+ and K+) in vascular smooth muscle cells and cardiomyocytes
Cardiovascular effects of polyphenols
Cardiovascular liabilities of novel multidrug resistance reverting agents and antineoplastic drugs
Expertise
Cell viability assays (necrosis, apoptosis, autophagy, cell cycle analysis), mitochondrial function, redox state, cell imaging
Patch-clamp analysis of ionic currents (Na+, Ca2+ and K+ channels, i.e. Kv11.1(hERG) - the target of virtually all QT interval-prolonging torsadogenic drugs) in single cell;
Evaluation of vascular responsiveness to various agents in rat aorta rings and single myocytes
Evaluation of cardiac function and ECG recording in Langendorff-perfused rat heart. Assessment of cardiac damage in homogenized hearts and concentrated coronary effluent (assessment of creatine kinase and troponin T, NT-proBNP)
Ultime pubblicazioni:
- Carullo, G., Falbo, F., Tudino, V., Song, J., Fava, M., Fontana, A., et al. (2026). Targeting Class I Histone Deacetylases Triggers Antitumor Responses in Colorectal Cancer In Vitro and In Vivo. JOURNAL OF MEDICINAL CHEMISTRY, 69(2), 1049-1074 [10.1021/acs.jmedchem.5c02237]. - view more
- Fusi, F., Saponara, S., Carullo, G., Panti, A., Bichicchi, A., Pifferi, A., et al. (2025). The insulin-releasing agent quercetin-3-oleate stimulates CaV1.2 channels similarly to quercetin, though with a reduced vasorelaxant activity. EUROPEAN JOURNAL OF PHARMACOLOGY, 1003 [10.1016/j.ejphar.2025.177902]. - view more
- Fontana, A., Bergantini, L., Carullo, G., Scalvini, L., D'Alessandro, M., Papulino, C., et al. (2025). Spirotetrahydroisoquinoline-Based Histone Deacetylase Inhibitors as New Antifibrotic Agents: Biological Evaluation in Human Fibroblasts from Bronchoalveolar Lavages of Idiopathic Pulmonary Fibrosis Patients. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 8(2), 380-393 [10.1021/acsptsci.4c00456]. - view more
- Cursaro, I., Frattaruolo, L., Scalvini, L., Contri, C., Bichicchi, A., Tardiolo, N., et al. (2025). New Vanillyl-capped HDAC inhibitors exhibit anti-tumor efficacy in neuroblastoma and glioblastoma cells. BIOORGANIC CHEMISTRY, 166 [10.1016/j.bioorg.2025.109085]. - view more
- Koszelewski, D., Ostaszewski, R., Zaremba, A., Riganti, C., Kopecka, J., Contino, M., et al. (2025). New dimension of ciprofloxacin hybrids: Synthesis, characterization and anticancer evaluation of newly C3-modified ciprofloxacin derivatives. BIOORGANIC CHEMISTRY, 164 [10.1016/j.bioorg.2025.108863]. - view more