SAPONARA SIMONA
Office hours
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Monday from 09:30 to 11:30Place: Studio del docente - Polo Scientifico Universitario di San MiniatoNote: Previo appuntamento
Curriculum Vitae
Teaching activities
Completion accademic year: 2025/2026
Completion accademic year: 2024/2025
Completion accademic year: 2023/2024
Research
Research Interests
Novel natural as well synthetic modulators of ionic currents (Ca2+ and K+) in vascular smooth muscle cells and cardiomyocytes
Cardiovascular effects of polyphenols
Cardiovascular liabilities of novel multidrug resistance reverting agents and antineoplastic drugs
Expertise
Cell viability assays (necrosis, apoptosis, autophagy, cell cycle analysis), mitochondrial function, redox state, cell imaging
Patch-clamp analysis of ionic currents (Na+, Ca2+ and K+ channels, i.e. Kv11.1(hERG) - the target of virtually all QT interval-prolonging torsadogenic drugs) in single cell;
Evaluation of vascular responsiveness to various agents in rat aorta rings and single myocytes
Evaluation of cardiac function and ECG recording in Langendorff-perfused rat heart. Assessment of cardiac damage in homogenized hearts and concentrated coronary effluent (assessment of creatine kinase and troponin T, NT-proBNP)
Ultime pubblicazioni:
- Medana, C., Spizzirri, U.G., Schiavo, V., Fusi, F., Panti, A., Saponara, S., et al. (2024). Screening of the antioxidant and vasorelaxant activity of wine waste ultrasonic extracts, and HRMS targeted and semi-targeted profiling of glycosylated polyphenols vs free polyphenols. LEBENSMITTEL-WISSENSCHAFT + TECHNOLOGIE, 208 [10.1016/j.lwt.2024.116666]. - view more
- Carullo, G., Orsini, N., Piano, I., Pozzetti, L., Papa, A., Fontana, A., et al. (2024). Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy. JOURNAL OF MEDICINAL CHEMISTRY, 67(17), 14946-14973 [10.1021/acs.jmedchem.4c00477]. - view more
- Fontana, A., Bergantini, L., Carullo, G., Scalvini, L., D'Alessandro, M., Papulino, C., et al. (2024). Spirotetrahydroisoquinoline-Based Histone Deacetylase Inhibitors as New Antifibrotic Agents: Biological Evaluation in Human Fibroblasts from Bronchoalveolar Lavages of Idiopathic Pulmonary Fibrosis Patients. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE [10.1021/acsptsci.4c00456]. - view more
- Carullo, G., Borghini, F., Fusi, F., Saponara, S., Fontana, A., Pozzetti, L., et al. (2024). Traceability and authentication in agri-food production: A multivariate approach to the characterization of the Italian food excellence elephant garlic (Allium ampeloprasum L.), a vasoactive nutraceutical. FOOD CHEMISTRY, 444 [10.1016/j.foodchem.2024.138684]. - view more
- Fusi, F., Saponara, S., Brimble, M.A., Rennison, D., Hopkins, B., Bova, S. (2024). The Enigma of Norbormide, a Rattus-Selective Toxicant. CELLS, 13(9) [10.3390/cells13090788]. - view more