SAPONARA SIMONA

Simona
Saponara
Professore Associato

Office hours

  • Monday from 09:30 to 11:30
    Place: Studio del docente - Polo Scientifico Universitario di San Miniato
    Note: Previo appuntamento

Curriculum Vitae

Teaching activities

Completion accademic year: 2022/2023

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2020/2021
Course year: 2 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2021/2022

Completion accademic year: 2021/2022

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2019/2020
Course year: 2 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2020/2021

Completion accademic year: 2020/2021

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2018/2019

Completion accademic year: 2019/2020

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2017/2018
Course year: 1 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2019/2020

Research

Research Interests

Novel natural as well synthetic modulators of ionic currents (Ca2+ and K+) in vascular smooth muscle cells and cardiomyocytes

Cardiovascular effects of polyphenols

Cardiovascular liabilities of novel multidrug resistance reverting agents and antineoplastic drugs

 

Expertise

Cell viability assays (necrosis, apoptosis, autophagy, cell cycle analysis), mitochondrial function, redox state, cell imaging

Patch-clamp analysis of ionic currents (Na+, Ca2+ and K+ channels, i.e. Kv11.1(hERG) - the target of virtually all QT interval-prolonging torsadogenic drugs) in single cell;

Evaluation of vascular responsiveness to various agents in rat aorta rings and single myocytes

Evaluation of cardiac function and ECG recording in Langendorff-perfused rat heart. Assessment of cardiac damage in homogenized hearts and concentrated coronary effluent (assessment of creatine kinase and troponin T, NT-proBNP)

 

Ultime pubblicazioni:

  • Papa, A., Pasquini, S., Galvani, F., Cammarota, M., Contri, C., Carullo, G., et al. (2022). Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 246 [10.1016/j.ejmech.2022.114952]. - view more
  • Durante, M., Frosini, M., Chiaino, E., Fusi, F., Gamberucci, A., Gorelli, B., et al. (2022). Sdox, a H2S releasing anthracycline, with a safer profile than doxorubicin toward vasculature. VASCULAR PHARMACOLOGY, 143, 1-8 [10.1016/j.vph.2022.106969]. - view more
  • Fallani, E., Cevenini, F., Lazzerini, P.E., Verdini, A., Saponara, S. (2022). Off-label use of hydroxychloroquine in COVID-19: analysis of reports of suspected adverse reactions from the Italian National Network of Pharmacovigilance. THE JOURNAL OF CLINICAL PHARMACOLOGY, 62(5), 646-655 [10.1002/jcph.2006]. - view more
  • Carullo, G., Falbo, F., Ahmed, A., Trezza, A., Gianibbi, B., Nicolotti, O., et al. (2022). Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: Synthesis and biological evaluation. BIOORGANIC CHEMISTRY, 131, 1-11 [10.1016/j.bioorg.2022.106326]. - view more
  • Cuong, N.M., Son, N.T., Nhan, N.T., Fukuyama, Y., Ahmed, A., Saponara, S., et al. (2022). Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators. MOLECULES, 27(14), 4505 [10.3390/molecules27144505]. - view more