SAPONARA SIMONA

Simona
Saponara
Professore Associato

Office hours

  • Monday from 09:30 to 11:30
    Place: Studio del docente - Polo Scientifico Universitario di San Miniato
    Note: Previo appuntamento

Curriculum Vitae

Teaching activities

Completion accademic year: 2024/2025

Course year: 1 Second cycle degree (Laurea Magistrale) BIOLOGY A.Y. 2024/2025
Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2022/2023
Course year: 5 Full cicle (5 years) PHARMACY A.Y. 2020/2021
Course year: 2 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2023/2024

Completion accademic year: 2023/2024

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2021/2022
Course year: 2 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2022/2023

Completion accademic year: 2022/2023

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2020/2021
Course year: 2 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2021/2022

Completion accademic year: 2021/2022

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2019/2020

Research

Research Interests

Novel natural as well synthetic modulators of ionic currents (Ca2+ and K+) in vascular smooth muscle cells and cardiomyocytes

Cardiovascular effects of polyphenols

Cardiovascular liabilities of novel multidrug resistance reverting agents and antineoplastic drugs

 

Expertise

Cell viability assays (necrosis, apoptosis, autophagy, cell cycle analysis), mitochondrial function, redox state, cell imaging

Patch-clamp analysis of ionic currents (Na+, Ca2+ and K+ channels, i.e. Kv11.1(hERG) - the target of virtually all QT interval-prolonging torsadogenic drugs) in single cell;

Evaluation of vascular responsiveness to various agents in rat aorta rings and single myocytes

Evaluation of cardiac function and ECG recording in Langendorff-perfused rat heart. Assessment of cardiac damage in homogenized hearts and concentrated coronary effluent (assessment of creatine kinase and troponin T, NT-proBNP)

 

Ultime pubblicazioni:

  • Carullo, G., Borghini, F., Fusi, F., Saponara, S., Fontana, A., Pozzetti, L., et al. (2024). Traceability and authentication in agri-food production: A multivariate approach to the characterization of the Italian food excellence elephant garlic (Allium ampeloprasum L.), a vasoactive nutraceutical. FOOD CHEMISTRY, 444 [10.1016/j.foodchem.2024.138684]. - view more
  • Fusi, F., Saponara, S., Brimble, M.A., Rennison, D., Hopkins, B., Bova, S. (2024). The Enigma of Norbormide, a Rattus-Selective Toxicant. CELLS, 13(9) [10.3390/cells13090788]. - view more
  • Papa, A., Pasquini, S., Galvani, F., Cammarota, M., Contri, C., Carullo, G., et al. (2023). Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 246 [10.1016/j.ejmech.2022.114952]. - view more
  • Rango, E., Di Maria, S., Zamperini, C., Poggialini, F., Crespan, E., Perini, C., et al. (2023). Tyrosine Kinase Inhibitor Si409 Has In Vitro and In Vivo Anti-Tumor Activity Against Diffuse Large B-Cell Lymphoma. PHARMACEUTICAL CHEMISTRY JOURNAL, 56(12), 1616-1626 [10.1007/s11094-023-02836-x]. - view more
  • Luca Michele, D.e., Restuccia, D., Gianfranco Spizzirri, U., Crupi, P., Ioele, G., Gorelli, B., et al. (2023). Wine Lees as Source of Antioxidant Molecules: Green Extraction Procedure and Biological Activity. ANTIOXIDANTS, 12(3) [10.3390/antiox12030622]. - view more