SAPONARA SIMONA

Simona
Saponara
Ricercatore universitario

Office hours

  • Monday from 09:30 to 11:30
    Place: Studio del docente - Polo Scientifico Universitario di San Miniato
    Note: Previo appuntamento

Curriculum Vitae

Teaching activities

Completion accademic year: 2020/2021

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2018/2019

Completion accademic year: 2019/2020

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2017/2018
Course year: 1 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2019/2020

Completion accademic year: 2018/2019

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2016/2017
Course year: 1 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2018/2019

Completion accademic year: 2017/2018

Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2015/2016
Course year: 1 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2017/2018
Course year: 2 First cycle degree (DM 270) CARDIOCIRCULATORY AND CARDIOVASCULAR PERFUSION TECHNIQUES A.Y. 2016/2017

Research

Research Interests

Novel natural as well synthetic modulators of ionic currents (Ca2+ and K+) in vascular smooth muscle cells and cardiomyocytes

Cardiovascular effects of polyphenols

Cardiovascular liabilities of novel multidrug resistance reverting agents and antineoplastic drugs

 

Expertise

Cell viability assays (necrosis, apoptosis, autophagy, cell cycle analysis), mitochondrial function, redox state, cell imaging

Patch-clamp analysis of ionic currents (Na+, Ca2+ and K+ channels, i.e. Kv11.1(hERG) - the target of virtually all QT interval-prolonging torsadogenic drugs) in single cell;

Evaluation of vascular responsiveness to various agents in rat aorta rings and single myocytes

Evaluation of cardiac function and ECG recording in Langendorff-perfused rat heart. Assessment of cardiac damage in homogenized hearts and concentrated coronary effluent (assessment of creatine kinase and troponin T, NT-proBNP)

 

Latest publications:

  • Fusi, F., Trezza, A., Tramaglino, M., Sgaragli, G., Saponara, S., & Spiga, O. (2020). The beneficial health effects of flavonoids on the cardiovascular system: focus on K+ channels. PHARMACOLOGICAL RESEARCH, 152, 1-27. - view more
  • Assaraf, Y.G., Brozovic, A., Cristina Gonçalves, A., Jurkovicova, D., Linē, A., Machuqueiro, M., et al. (2019). The multi-factorial nature of clinical multidrug resistance in cancer. DRUG RESISTANCE UPDATES, 46, 1-30. - view more
  • Saponara, S., Fusi, F., Spiga, O., Trezza, A., Hopkins, B., Brimble, M.A., et al. (2019). The selective rat toxicant norbormide blocks KATP channels in smooth muscle cells but not in insulin-secreting cells. FRONTIERS IN PHARMACOLOGY, 10(MAY), 1-11. - view more
  • Carullo, G., Durante, M., Sciubba, F., Restuccia, D., Spizzirri, U.G., Ahmed, A., et al. (2019). Vasoactivity of Mantonico and Pecorello grape pomaces on rat aorta rings: An insight into nutraceutical development. JOURNAL OF FUNCTIONAL FOODS, 57, 328-334. - view more
  • Gazzano, E., Buondonno, I., Marengo, A., Rolando, B., Chegaev, K., Kopecka, J., et al. (2019). Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts. CANCER LETTERS, 456, 29-39. - view more