PERNI STEFANO

Stefano
Perni
Dipartimento di Medicina Molecolare e dello Sviluppo
Professore Associato

Presentation

My work mostly focuses on two main ongoing projects:

1) Study of the reciprocal interactions among calcium signaling proteins in the plasma membrane-endoplasmic reticulum junctions (ER-PM junctions) microdomain in muscle and neurons, with particular emphasis on junctophilin and voltage-dependent calcium channels (CaVs) and calcium release channels (RyRs).

2) Strategies for the in-vivo administration of muscle-specific mirco-RNAs and their protective effects on the structure, function, and metabolism of muscle from mice affected by congenital myopathies.

Office hours

Office location: Polo Scientifico San Miniato, Room A_02_38 a.

Please contact me via email to schedule an appointment in advance

Contacts

stefano.perni@unisi.it
0577232833 [int.2833]

Curriculum Vitae

cv

Teaching activities

Research

Ultime pubblicazioni:

  • Rossi, D., Pranzo, C., Roccabianca, S., Galli, L., Orrico, A., Sorbello, G., et al. (2026). Identification of novel potentially causative RYR1 variants in individuals with malignant hyperthermia susceptibility. NEUROMUSCULAR DISORDERS, 58 [10.1016/j.nmd.2025.106296]. - view more
  • Perni, S., Polster, A., Beam, K.G. (2025). Interaction between CaV2.1 and Junctophilin3/4 depends on the II-III loop of CaV2.1 and on the α-helical region of Junctophilin3/4. THE JOURNAL OF BIOLOGICAL CHEMISTRY [10.1016/j.jbc.2025.108424]. - view more
  • Serano, M., Perni, S., Pierantozzi, E., Laurino, A., Sorrentino, V., Rossi, D. (2025). Intracellular membrane contact sites in skeletal muscle cells. MEMBRANES, 15(1) [10.3390/membranes15010029]. - view more
  • Crocini, C., Woulfe, K.C., Ozeroff, C.D., Perni, S., Cardiello, J., Walker, C.J., et al. (2024). Postprandial cardiac hypertrophy is sustained by mechanics, epigenetic, and metabolic reprogramming in pythons. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 121(36) [10.1073/pnas.2322726121]. - view more
  • Dayal, A., Perni, S., Franzini-Armstrongc, C., Beam, K.G., Grabner, M. (2022). The distal C terminus of the dihydropyridine receptor β1a subunit is essential for tetrad formation in skeletal muscle. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(19) [10.1073/pnas.2201136119]. - view more
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