GEMMA SANDRA

Sandra
Gemma
Professore Associato

Office hours

  • Monday from 09:00 to 11:00
    Place: Aula virtuale o studio docente presso il DBCF (stanza 10.165)
    Note: Il docente è disponibile a ricevere gli studenti anche in orari e giorni diversi da quello indicato previo appuntamento da effettuarsi telefonicamente o per e-mail

Notices

Research topics for experimental theses:

-Design and synthesis of new trypanothione reductase inhibitors as anti-leishmania agents

-New antivirals: synthesis of SARS-CoV-2 protease inhibitors

-ESKAPE pathogens: new structural scaffolds capable of interfering with quorum sensing mechanisms

-Design and synthesis of new trypanothione reductase inhibitors as anti-leishmania agents

-New antivirals: synthesis of SARS-CoV-2 protease inhibitors

-ESKAPE pathogens: new structural scaffolds capable of interfering with quorum sensing mechanisms

Pharmacy and CTF students interested in conducting an experimental thesis in pharmaceutical chemistry can reach out to Professor Gemma for more information on available research opportunities - places available!

Teaching activities

Completion accademic year: 2024/2025

Course year: 4 Full cicle (5 years) PHARMACY A.Y. 2021/2022
Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2022/2023

Completion accademic year: 2023/2024

Course year: 4 Full cicle (5 years) PHARMACY A.Y. 2020/2021
Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2021/2022

Completion accademic year: 2022/2023

Completion accademic year: 2021/2022

Course year: 5 Full cicle (5 years) PHARMACY A.Y. 2017/2018
Course year: 3 Full cicle (5 years) PHARMACY A.Y. 2019/2020

Research

Professor Gemma's research activity is primarily focused on the design, synthesis, and optimization of therapeutic tools for the treatment of various pathological conditions. For many years, her research has been centered around identifying antiviral and antiparasitic agents through various design strategies, such as synthesizing and modifying natural compounds, structure-based drug design, and developing synthetic methodologies for compound libraries to study structure-activity relationships.

Research topics

In her pursuit of advancing treatment against Leishmania, Professor Gemma is engaged in the design and synthesis of novel trypanothione reductase inhibitors. These inhibitors hold the potential to combat the Leishmania parasite effectively and offer new therapeutic avenues for addressing this disease.

Additionally, she is actively involved in the development of new antivirals, specifically focusing on synthesizing SARS-CoV-2 protease inhibitors. These antivirals play a critical role in combatting the SARS-CoV-2 virus responsible for the COVID-19 pandemic and may contribute significantly to global health efforts.

Furthermore, Professor Gemma's research delves into combating ESKAPE pathogens, which are known for their resistance to multiple antibiotics. Her work revolves around identifying and designing new structural scaffolds that can interfere with quorum sensing mechanisms in these pathogens, offering potential breakthroughs in combating antibiotic-resistant infections.

Synthetic chemistry

Throughout my years of research activity, I have cultivated a strong foundation and expertise in organic chemistry. Whenever required for medicinal chemistry projects, I have successfully devised appropriate synthetic strategies for the stereoselective preparation of natural compounds, including dihydroplakortin and its epimers and lophirone A. Additionally, I have undertaken the synthesis of analogues of natural alkaloids like huperzine A, and I have also developed synthetic methodologies to create specific heterocyclic scaffolds such as benzodiazepines, benzoxazepines, peroxides, and quinolines with precise decoration patterns.

Ultime pubblicazioni:

  • Fedeli, R., Spizzirri, U.G., Aquino, G., Basilicata, M.G., Pepe, G., Campiglia, P., et al. (2024). Biostimulants for Sustainable Food Production: Effects of Wood Distillate to Fortify Chickpea Flour for Development of Functional Bakery Products. ACS FOOD SCIENCE & TECHNOLOGY [10.1021/acsfoodscitech.4c00098]. - view more
  • Falbo, F., Gemma, S., Koch, A., Mazzotta, S., Carullo, G., Ramunno, A., et al. (2024). Synthetic derivatives of natural cinnamic acids as potential anti-colorectal cancer agents. CHEMICAL BIOLOGY & DRUG DESIGN, 103(1) [10.1111/cbdd.14415]. - view more
  • Carullo, G., Borghini, F., Fusi, F., Saponara, S., Fontana, A., Pozzetti, L., et al. (2024). Traceability and authentication in agri-food production: A multivariate approach to the characterization of the Italian food excellence elephant garlic (Allium ampeloprasum L.), a vasoactive nutraceutical. FOOD CHEMISTRY, 444 [10.1016/j.foodchem.2024.138684]. - view more
  • Rossi, S., Tatangelo, V., Dichiara, M., Butini, S., Gemma, S., Brogi, S., et al. (2024). A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients. BIOMÉDECINE & PHARMACOTHÉRAPIE, 174 [10.1016/j.biopha.2024.116537]. - view more
  • Butini, S., Grether, U., Jung, K., Ligresti, A., Allarà, M., Postmus, A.G.J., et al. (2024). Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization. JOURNAL OF MEDICINAL CHEMISTRY, 67(3), 1758-1782 [10.1021/acs.jmedchem.3c01278]. - view more