BUTINI STEFANIA
Office hours
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Friday from 11:30 to 12:30Place: Stanza 10167, Polo Scientifico S. Miniato, si prega di inviare e-mail per verificare la disponibilità. Per motivi di sicurzza il docente riceve presso l'aula virtuale del sito docente (https://docenti.unisi.it/it/butini) secondo le stesse modalità
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If didactic activities are scheduled on Friday at the indicated time (please check the lessons' timetable), you are kindly asked to contact the teacher via e-mail
Contacts
Curriculum Vitae
Teaching activities
Completion accademic year: 2026/2027
Completion accademic year: 2025/2026
Completion accademic year: 2024/2025
Completion accademic year: 2023/2024
Research
Prof Stefania Butini is associate professor of medicinal chemistry since 2015. She earned the degree of chemistry and pharmaceutical technology at the University of Siena in 1997 and a PhD in pharmaceutical sciences at the same University in 2000. In 1999-2000 she spent a period of internship at the University of Groningen under the supervision of Prof H.W. Wikström working on Parkinson Disease and the development of dopamine D3 receptor modulators. In 2004 she became permanent senior researcher at the University of Siena.
Her research activity focuses on the development of bioactive compounds with a special emphasis on CNS diseases, antimalarial, and antitumor agents. Exploration of chemistry and biology of synthetic organic molecules with therapeutic potential in neurodegenerative and neuropsychiatric diseases is a key part her research interests that include target selection, rational design of innovative drugs, discovery of new synthetic methodologies, and general strategies for synthesis, bioinformatics and the study of structure-function relationships. She is experienced as Research Units’ coordinator in National and International polycentric research projects dealing with drug development in various fields.
Ultime pubblicazioni:
- Carullo, G., Falbo, F., Tudino, V., Song, J., Fava, M., Fontana, A., et al. (2026). Targeting class I histone deacetylases triggers antitumor responses in colorectal cancer in vitro and in vivo. JOURNAL OF MEDICINAL CHEMISTRY, 69(2), 1049-1074 [10.1021/acs.jmedchem.5c02237]. - view more
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Tudino, V., Mellini, M., Milioni, L., Carullo, G., Rossi, S., Giammarino, F.M.P.R., et al. (2026). Quinazolinone-Based PqsR Modulators Suppress Quorum-Sensing–Driven Virulence in
Pseudomonas aeruginosa. ACS INFECTIOUS DISEASES, 12(3), 1176-1191 [10.1021/acsinfecdis.5c01128]. - view more - Cursaro, I., Ciccone, V., Tudino, V., Papulino, C., Scalvini, L., Donnini, S., et al. (2025). Reversing TGF-β1-induced fibrotic phenotype in human lung fibroblasts using a PROTAC tool derived from an indoline-based HDAC6 inhibitor. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS, 14 [10.1016/j.ejmcr.2025.100276]. - view more
- Fedeli, R., Ranzato, E., Martinotti, S., Basilicata, M.G., Marotta, L., Fava, M., et al. (2025). Unveiling Wound Healing Properties of Biostimulated Walnut Kernel Extracts via Epithelial Mesenchymal Transition: Switching a Nutritional Matrix into a Therapeutic Remedy. ANTIOXIDANTS, 14(9) [10.3390/antiox14091079]. - view more
- Fontana, A., Bergantini, L., Carullo, G., Scalvini, L., D'Alessandro, M., Papulino, C., et al. (2025). Spirotetrahydroisoquinoline-Based Histone Deacetylase Inhibitors as New Antifibrotic Agents: Biological Evaluation in Human Fibroblasts from Bronchoalveolar Lavages of Idiopathic Pulmonary Fibrosis Patients. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 8(2), 380-393 [10.1021/acsptsci.4c00456]. - view more