BUTINI STEFANIA
Office hours
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Friday from 11:30 to 12:30Place: Stanza 10167, Polo Scientifico S. Miniato, si prega di inviare e-mail per verificare la disponibilità. Per motivi di sicurzza il docente riceve presso l'aula virtuale del sito docente (https://docenti.unisi.it/it/butini) secondo le stesse modalità
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If didactic activities are scheduled on Friday at the indicated time (please check the lessons' timetable), you are kindly asked to contact the teacher via e-mail
Contacts
Curriculum Vitae
Teaching activities
Completion accademic year: 2025/2026
Completion accademic year: 2024/2025
Completion accademic year: 2023/2024
Completion accademic year: 2022/2023
Research
Prof Stefania Butini is associate professor of medicinal chemistry since 2015. She earned the degree of chemistry and pharmaceutical technology at the University of Siena in 1997 and a PhD in pharmaceutical sciences at the same University in 2000. In 1999-2000 she spent a period of internship at the University of Groningen under the supervision of Prof H.W. Wikström working on Parkinson Disease and the development of dopamine D3 receptor modulators. In 2004 she became permanent senior researcher at the University of Siena.
Her research activity focuses on the development of bioactive compounds with a special emphasis on CNS diseases, antimalarial, and antitumor agents. Exploration of chemistry and biology of synthetic organic molecules with therapeutic potential in neurodegenerative and neuropsychiatric diseases is a key part her research interests that include target selection, rational design of innovative drugs, discovery of new synthetic methodologies, and general strategies for synthesis, bioinformatics and the study of structure-function relationships. She is experienced as Research Units’ coordinator in National and International polycentric research projects dealing with drug development in various fields.
Ultime pubblicazioni:
- Carullo, G., Falbo, F., Tudino, V., Song, J., Fava, M., Fontana, A., et al. (2026). Targeting class I histone deacetylases triggers antitumor responses in colorectal cancer in vitro and in vivo. JOURNAL OF MEDICINAL CHEMISTRY, 69(2), 1049-1074 [10.1021/acs.jmedchem.5c02237]. - view more
- Fedeli, R., Ranzato, E., Martinotti, S., Basilicata, M.G., Marotta, L., Fava, M., et al. (2025). Unveiling Wound Healing Properties of Biostimulated Walnut Kernel Extracts via Epithelial Mesenchymal Transition: Switching a Nutritional Matrix into a Therapeutic Remedy. ANTIOXIDANTS, 14(9) [10.3390/antiox14091079]. - view more
- Cursaro, I., Milioni, L., Eslami, K., Sirous, H., Carullo, G., Gemma, S., et al. (2025). Targeting N‐Methyl‐lysine Histone Demethylase KDM4 in Cancer: Natural Products Inhibitors as a Driving Force for Epigenetic Drug Discovery. CHEMMEDCHEM, 20(4) [10.1002/cmdc.202400682]. - view more
- Carullo, G., Piano, I., Salamone, G., Corsi, F., Orsini, N., Dichiara, M., et al. (2025). Uncovering a Mutation-Independent Therapeutic Strategy against Inherited Retinal Diseases: Development of Class I HDAC/LSD1 Hybrid Inhibitors. ACS CHEMICAL NEUROSCIENCE, 16(17), 3364-3384 [10.1021/acschemneuro.5c00457]. - view more
- Fontana, A., Bergantini, L., Carullo, G., Scalvini, L., D'Alessandro, M., Papulino, C., et al. (2025). Spirotetrahydroisoquinoline-Based Histone Deacetylase Inhibitors as New Antifibrotic Agents: Biological Evaluation in Human Fibroblasts from Bronchoalveolar Lavages of Idiopathic Pulmonary Fibrosis Patients. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 8(2), 380-393 [10.1021/acsptsci.4c00456]. - view more