Marco Casini received the Laurea degree in Information Engineering (cum laude) and the Ph.D. degree in Information Engineering from the University of Siena, Siena, Italy, in 1999 and 2003, respectively. From May 2002 to December 2004, he was a Research Associate with the Dipartimento di Ingegneria dell'Informazione, Università di Siena. From January 2005 to February 2021 he was an Assistant Professor with Dipartimento di Ingegneria dell'Informazione e Scienze Matematiche (DIISM), Università di Siena. Since March 2021 he serves as Associate Professor at the same department. Since 2008, he is the scientific coordinator of the Systems and Control Laboratory at DIISM.

He taught the following courses in the field of control systems: "control systems design", "control systems technology", "remote lab of control systems", "multivariable, nonlinear and robust control", "system identification and data anlysis". He was member of the committees for the final evaluation of the Ph.D. candidates at Università di Siena and Politecnico of Torino (Italy).

In summer 2001, he was a visiting researcher at the Laboratory for Information and Decision Systems (LIDS) at the Massachusetts Institute of Technology (MIT), Cambridge, MA. In July 2010, he teached the Ph.D. course "Set Membership Estimation: Theory and Applications" at the Universitat Politècnica de València, Valencia, Spain.

His research interests include set-membership system identification and modeling, smart grids and optimal energy management, differential games. He worked also on decision support systems for environmental applications and remote laboratories of automatic control. As a recognition for his research activity, he was awarded the grant FFABR 2017 by the Italian Ministry for Education, University and Research. He has been a reviewer for the most prestigious journals and conferences of the control and power system communities.

He participated in the following EU project:
- ACANTO: A CyberphysicAl social NeTwOrk using robot friends (2015-18);
- DALi: Devices for Assisted Living (2011-14);
- ADDRESS: Active Distribution network with full integration of Demand and distributed energy RESourceS (2008-12);
- DITTY: Development of an information technology tool for the management of European Southern lagoons under the influence of river-basin runoff (2003-06).
Moreover, he participated in the following Research Projects of National Interest (PRIN):
- PRIN 2017: Monitoring and control underpinning the energy-aware factory of the future: novel methodologies and industrial validation;
- PRIN 2006: Tecniche avanzate di controllo e identificazione per applicazioni innovative;
- PRIN 2005: Tecniche robuste per l'analisi ed il controllo di sistemi dinamici incerti;
- PRIN 2004: Tecniche robuste e di ottimizzazione per sistemi di controllo ad alte prestazioni;
- PRIN 2002: Tecniche robuste e di ottimizzazione per il controllo di sistemi incerti;
- PRIN 2000: Tecniche robuste per il controllo di sistemi incerti
In 2019, he was the coordinator of the funded project "development of experimental setups for multi-agent systems" in the PSR F-LAB framework of the Università di Siena.

From 2005 to 2010 he carried out industrial research activity in funded projects from the Italian Ministry of Economic Development (MISE). He is coauthor of the Italian patent "integrated system for psycho-ergometic sensing" (2008), and of the software (copyright) "Software for building a remote laboratory of control systems" (2001).

He was the organizer of the invited session "Recent Advances in Remote Labs for Control Education”, 10th IFAC Symposium on Advances in Control Education (Sheffield, 2013). He was co-organizer of the invited sessions "Challenges in system identification: piecewise affine models and quantized information", 16th IFAC Symposium on System Identification (Brussels, 2012), and "LEGO Mindstorms NXT in Control Education", 18th IFAC World Congress (Milano, 2011).

He is a member of the Institute of Electrical and Electronics Engineers (IEEE), and of the IEEE Control Systems Society, where he serves as a member of the Technical Committee on System Identification and Adaptive Control. He is also member of the International Federation of Automatic Control (IFAC) where he serves as a member of the Educational Committee.

He is the author or co-author of more than 60 papers in peer-reviewed journals, edited books, and conference proceedings. As of March 17, 2023, his bibliometric indices are h-index 16 (Scopus) – 21 (Scholar), and number of citations 1118 (Scopus) – 1855 (Scholar).